I have Multiple Sclerosis and on my right foot I have numbness. sometimes pain. I also deal with 24/7 extreme pain and unpredictable in the severity of the pain. These shoes don’t take the pain away but make it so much moore comfortable to walk. It has a wide toe box that allows your toes to spread out w room to spare. Inside the shoe I’m not sure of the material but it’s a soft fuzzy cotton that feels good to your feet, doesn’t squeeze your feet, a big no no w foot pain. And the most important feature of this shoe is the INSOLE it’s so comfortable, their is cushion material, again not sure what it’s made of, molds to feet your over time but still keeps that cushion feel. To be honest I initially ordered the shoes because I liked the look, wanted a hard sole house shoes I could take outside. When I received them, just WOW! I’ve wired them to the Y to work out in the pool, to the grocery store, they are so damn comfortable. I bought 2 more pair for two good friends who have foot pain, they can’t say enough about them. Seems like they run tru to size but if you have foot pain you could go up a size, people w foot Neuropathy at least for me do not like a shoe that is tight. Love these Shies!